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Alyra Therapeutics

Alyra TherapeuticsAlyra TherapeuticsAlyra Therapeutics

Next-generation precision oncology

Alyra Therapeutics

Alyra TherapeuticsAlyra TherapeuticsAlyra Therapeutics

Next-generation precision oncology

About Us

Who We Are

Where We Are

Who We Are

 Headquartered in San Diego, CA with collaborators in Irvine, CA, Austin, TX and Genoa, Italy, we are a team of academic scientists and veteran pharmaceutical industry executives focused on developing novel first-in-class protein-protein interaction inhibitors for the treatment of cancer and rare diseases.

What We Do

Where We Are

Who We Are

Using an innovative drug discovery platform that integrates computational chemistry and both intracellular and biophysical assay technologies we have identified allosteric inhibitors of the ras-family GTPases RHOJ and CDC42 that block the signaling interaction between these proteins and their respective PAK family protein kinase effectors.

Where We Are

Where We Are

Where We Are

We are focused on our clinical lead compound, ALY101. A highly selective inhibitor of tumor growth and angiogenesis, ALY101 has activity against melanoma tumors in both in vitro and in vivo settings and has demonstrated the potential to impact the treatment of additional cancers as well as multiple rare diseases.

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